Metabolic Study of Isoproturon in Goats Following a Single Oral Administration:  Toxicokinetics and Recovery

Toxicokinetic behavior and recoveries of isoproturon from feces, urine, and different tissues of goat were determined after 4, 5, 6, and 7 days following single oral administration at 500 mg/kg. Isoproturon was rapidly absorbed and attained blood concentration within 15 min of administration. The kinetic behavior followed a two-compartment open model. The higher t 1/2(β) (9.78 ± 0.33 h) and V d area (4.49 ± 0.41 L/kg) associated with lower ClB (0.32 ± 0.02 L/kg/h) suggested slow elimination from the blood. Approximately 56% of the total administered compound was recovered from feces. The rate of excretion of isoproturon through feces was maximum at 48 h and could not be detected beyond 120 h. The excretion pattern of isoproturon through urine resembled that of feces, and approximately 10−11% was eliminated in urine. A maximum quantity of residue was detected in all tissues of goats slaughtered after 4 days followed by a substantial decline after day 5, and nothing could be detected after day 7. Histopathological study revealed that isoproturon produced moderate cellular changes like fatty degeneration in the liver and kidney and emphysema in the lung after 7 days post administration. Keywords: Toxicokinetics; recovery; isoproturon; goat; histopathology