Solubility of Dexamethasone in Supercritical Carbon Dioxide

Dexamethasone (DXMT) is a glucocorticoid that belongs to an important class of synthetic steroid hormones with potential to treat chronic immune and inflammatory diseases. In this work, the solid solubility of dexamethasone in supercritical carbon dioxide (scCO2) was measured using a static method. Experimental data were measured at (308.2, 318.2, and 328.2) K in the pressure range from (15.1 to 35.7) MPa. The solubility in scCO2 was found to be low and between (1.25·10–6 or 9.1·10–3) kg·m–3 (at 308.2 K and 15.1 MPa) and (2.81·10–6 or 22.0·10–3) kg·m–3 (at 328.2 K and 34.8 MPa) in terms of mole fraction or mass of drug per volume of solvent, respectively. Experimental data were correlated using semiempirical density based models (Méndez-Santiago–Teja, Bartle, and Chrastil). Obtained average absolute relative deviation [AARD (%)] values were lower than 13 %.