Solubility of Cannabinol in Supercritical Carbon Dioxide

Cannabinol (CBN) is a decomposition product of the cannabinoid (−)-Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10−4 to 4.16·10−4. CBN showed different behavior compared to Δ9-THC in terms of molar solubility. The data were correlated using the Peng−Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).