Co-Registered Molecular Logic Gate with a CO-Releasing Molecule Triggered by Light and Peroxide

Co-registered molecular logic gates combine two different inputs and outputs, such as light and matter. We introduce a biocompatible CO-releasing molecule (CORM, A) as Mn­(I) tricarbonyl complex with the ligand 5-(dimethylamino)-N, N-bis­(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release...

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Veröffentlicht in:Journal of the American Chemical Society 2017-04, Vol.139 (14), p.4991-4994
Hauptverfasser: G, Upendar Reddy, Axthelm, Jörg, Hoffmann, Patrick, Taye, Nandaraj, Gläser, Steve, Görls, Helmar, Hopkins, Samantha L, Plass, Winfried, Neugebauer, Ute, Bonnet, Sylvestre, Schiller, Alexander
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Sprache:eng
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Zusammenfassung:Co-registered molecular logic gates combine two different inputs and outputs, such as light and matter. We introduce a biocompatible CO-releasing molecule (CORM, A) as Mn­(I) tricarbonyl complex with the ligand 5-(dimethylamino)-N, N-bis­(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release is chaperoned by turn-on fluorescence and can be triggered by light (405 nm) as well as with hydrogen peroxide in aqueous phosphate buffer. Complex A behaves as a logic “OR” gate via co-registering the inputs of irradiation (light) and peroxide (matter) into the concomitant outputs fluorescence (light) and CO (matter). Cell viability assays confirm the low toxicity of A toward different human cell lines. The CORM has been used to track the inclusion of A into cancer cells.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.7b00867