Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation

Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation

A new and general method to functionalize the C­(sp3)–C­(sp2) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C­(sp3)–C­(sp2) cross-coupling. This one-pot protocol leverages the...

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Veröffentlicht in:Journal of the American Chemical Society 2021-09, Vol.143 (35), p.14046-14052
Hauptverfasser: Chen, Si-Cong, Zhu, Qi, Cao, Yuhui, Li, Chen, Guo, Yinliang, Kong, Lingran, Che, Jinteng, Guo, Zhixian, Chen, Han, Zhang, Nan, Fang, Xianhe, Lu, Jia-Tian, Luo, Tuoping
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Zusammenfassung:A new and general method to functionalize the C­(sp3)–C­(sp2) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C­(sp3)–C­(sp2) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.1c05092