A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

The total syntheses of complex sialylated cell-surface antigens have been accomplished. The target systems include 2,3-STF, STn, 2,6-STF, and glycophorin antigens. In addition, an α-O-linked serine glycoside of an entire Lewis blood group (Y) antigen has been assembled.

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Veröffentlicht in:Journal of the American Chemical Society 1999-03, Vol.121 (12), p.2662-2673
Hauptverfasser: Schwarz, Jacob B, Kuduk, Scott D, Chen, Xiao-Tao, Sames, Dalibor, Glunz, Peter W, Danishefsky, Samuel J
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container_end_page 2673
container_issue 12
container_start_page 2662
container_title Journal of the American Chemical Society
container_volume 121
creator Schwarz, Jacob B
Kuduk, Scott D
Chen, Xiao-Tao
Sames, Dalibor
Glunz, Peter W
Danishefsky, Samuel J
description The total syntheses of complex sialylated cell-surface antigens have been accomplished. The target systems include 2,3-STF, STn, 2,6-STF, and glycophorin antigens. In addition, an α-O-linked serine glycoside of an entire Lewis blood group (Y) antigen has been assembled.
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title A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues
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