A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

A Broadly Applicable Method for the Efficient Synthesis of α-O-Linked Glycopeptides and Clustered Sialic Acid Residues

The total syntheses of complex sialylated cell-surface antigens have been accomplished. The target systems include 2,3-STF, STn, 2,6-STF, and glycophorin antigens. In addition, an α-O-linked serine glycoside of an entire Lewis blood group (Y) antigen has been assembled.

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Veröffentlicht in:Journal of the American Chemical Society 1999-03, Vol.121 (12), p.2662-2673
Hauptverfasser: Schwarz, Jacob B, Kuduk, Scott D, Chen, Xiao-Tao, Sames, Dalibor, Glunz, Peter W, Danishefsky, Samuel J
Format: Artikel
Sprache:eng
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Zusammenfassung:The total syntheses of complex sialylated cell-surface antigens have been accomplished. The target systems include 2,3-STF, STn, 2,6-STF, and glycophorin antigens. In addition, an α-O-linked serine glycoside of an entire Lewis blood group (Y) antigen has been assembled.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja9833265