Enantioselective Nitroso Aldol Reaction Catalyzed by QuinoxP·Silver(I) Complex and Tin Methoxide
A catalytic enantioselective O-nitroso aldol reaction of alkenyl trichloroacetates with nitrosoarenes was achieved using the (R,R)-t-Bu-QuinoxP*·AgOAc complex as the chiral catalyst and Bu2Sn(OMe)2 as the achiral cocatalyst in the presence of methanol. Optically active α-aminooxy ketones with up to...
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| Veröffentlicht in: | Journal of the American Chemical Society 2010-04, Vol.132 (15), p.5328-5329 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A catalytic enantioselective O-nitroso aldol reaction of alkenyl trichloroacetates with nitrosoarenes was achieved using the (R,R)-t-Bu-QuinoxP*·AgOAc complex as the chiral catalyst and Bu2Sn(OMe)2 as the achiral cocatalyst in the presence of methanol. Optically active α-aminooxy ketones with up to 99% ee were regioselectively obtained in high yields from various alkenyl trichloroacetates of cyclic ketones. |
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| ISSN: | 0002-7863 1520-5126 |
| DOI: | 10.1021/ja910588w |