Pd(II)-Catalyzed Amination of C−H Bonds Using Single-Electron or Two-electron Oxidants

Pd(II)-Catalyzed Amination of C−H Bonds Using Single-Electron or Two-electron Oxidants

Pd(II)-catalyzed intramolecular amination of arenes is developed using either a one- or two-electron oxidant. The reaction protocol tolerates a wide range of deactivating groups including acetyl, cyano, and nitro groups. This catalytic reaction allows expedient syntheses of broadly useful substitute...

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Veröffentlicht in:Journal of the American Chemical Society 2009-08, Vol.131 (31), p.10806-10807
Hauptverfasser: Mei, Tian-Sheng, Wang, Xisheng, Yu, Jin-Quan
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Catalysis
Electrons
Indoles - chemical synthesis
Oxidants - chemistry
Palladium - chemistry
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Zusammenfassung:Pd(II)-catalyzed intramolecular amination of arenes is developed using either a one- or two-electron oxidant. The reaction protocol tolerates a wide range of deactivating groups including acetyl, cyano, and nitro groups. This catalytic reaction allows expedient syntheses of broadly useful substituted indolines or indoles.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja904709b