Optimal Control of Feeding in Fed-Batch Production of Xylitol

Optimal Control of Feeding in Fed-Batch Production of Xylitol

A model-based optimization involving a genetic algorithm was used to establish the optimal substrate feeding profiles in fed-batch fermentations for maximizing the average production rate of xylitol from xylose. The best-case feeding profiles were verified experimentally in fermentations fed with gl...

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Veröffentlicht in:Industrial & engineering chemistry research 2015-02, Vol.54 (7), p.1992-2000
Hauptverfasser: Tochampa, Worasit, Sirisansaneeyakul, Sarote, Vanichsriratana, Wirat, Srinophakun, Penjit, Bakker, Huub H. C, Wannawilai, Siwaporn, Chisti, Yusuf
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Sprache:eng
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Zusammenfassung:A model-based optimization involving a genetic algorithm was used to establish the optimal substrate feeding profiles in fed-batch fermentations for maximizing the average production rate of xylitol from xylose. The best-case feeding profiles were verified experimentally in fermentations fed with glucose and xylose. The model-predicted profiles agreed remarkably well with the measured data even though the model was based on parameter values derived from a batch fermentation.
ISSN:0888-5885
1520-5045
DOI:10.1021/ie5032937