Synthesis, Characterization, and Cytotoxicity of a Novel Highly Charged Trinuclear Platinum Compound. Enhancement of Cellular Uptake with Charge

Charge delocalization (6+ to 8+) in “noncovalent” linear trinuclear platinum complexes produces compounds with cytotoxicity in some cases equivalent to cisplatin. The cellular uptake of a novel 8+ compound is greater than that of neutral cisplatin as well as other multinuclear Pt compounds.

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Bibliographische Detailangaben
Veröffentlicht in:	Inorganic chemistry 2005-12, Vol.44 (26), p.9598-9600
Hauptverfasser:	Harris, Amanda L, Yang, Xiaohong, Hegmans, Alex, Povirk, Lawrence, Ryan, John J, Kelland, Lloyd, Farrell, Nicholas P
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Humans Molecular Structure Platinum Compounds - chemical synthesis Platinum Compounds - chemistry Platinum Compounds - toxicity
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Charge delocalization (6+ to 8+) in “noncovalent” linear trinuclear platinum complexes produces compounds with cytotoxicity in some cases equivalent to cisplatin. The cellular uptake of a novel 8+ compound is greater than that of neutral cisplatin as well as other multinuclear Pt compounds.
ISSN:	0020-1669 1520-510X
DOI:	10.1021/ic051390z