Copper x-ray absorption spectroscopic studies of the bovine plasma amine oxidase-sulfide complex

Copper x-ray absorption spectroscopic studies of the bovine plasma amine oxidase-sulfide complex

Substrate amines react with the organic cofactor of the bovine plasma amine oxidase and are oxidized to aldehydes. This reduces the enzyme by two electrons, and copper is required for the subsequent oxidation of the reduced enzyme by O/sub 2/ producing H/sub 2/O/sub 2/ and releasing NH/sub 3/. HS/su...

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Veröffentlicht in:Inorg. Chem.; (United States) 1988-10, Vol.27 (21), p.3859-3861
Hauptverfasser: Scott, Robert A, Cote, Cheryl E, Dooley, David M
Format: Artikel
Sprache:eng
Schlagworte:
550000 - Biomedical Sciences, Basic Studies
AMINES
ANIMALS
BASIC BIOLOGICAL SCIENCES
CATTLE
CHALCOGENIDES
COPPER COMPOUNDS
DOMESTIC ANIMALS
ENZYMES
MAMMALS
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PLASMA
RUMINANTS
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
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Zusammenfassung:Substrate amines react with the organic cofactor of the bovine plasma amine oxidase and are oxidized to aldehydes. This reduces the enzyme by two electrons, and copper is required for the subsequent oxidation of the reduced enzyme by O/sub 2/ producing H/sub 2/O/sub 2/ and releasing NH/sub 3/. HS/sup -/ has been proposed to initially bind to the enzyme forming a Cu/sup II/-SH/sup -/ complex, which then undergoes further reaction to eventually produce Cu(I) and the reduced organic cofactor as products. The results of an x-ray absorption spectroscopic study to characterize the structure of the Cu/sup II/-SH/sup -/ complex are reported. 25 references, 2 figures, 1 table.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic00294a035