Well-Defined Poly(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) Vectors with Low Toxicity and High Gene Transfection Efficiency

Successful gene delivery vectors for clinical translation should have high transfection efficiency and minimal toxicity. In this work, well-defined poly(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) (PGEA) vectors with flanking cationic secondary amine and nonionic hydroxyl units were prepa...

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Veröffentlicht in:	Biomacromolecules 2010-06, Vol.11 (6), p.1437-1442
Hauptverfasser:	Xu, F. J, Chai, M. Y, Li, W. B, Ping, Y, Tang, G. P, Yang, W. T, Ma, J, Liu, F. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Biological and medical sciences Cell Culture Techniques Cell Line Cell Survival - drug effects Chemical modifications Chemical reactions and properties Cloning, Molecular DNA - administration & dosage DNA - genetics Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - toxicity Exact sciences and technology Gene Transfer Techniques General pharmacology Humans Luciferases - genetics Medical sciences Molecular Structure Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Plasmids Polymethacrylic Acids - chemical synthesis Polymethacrylic Acids - chemistry Polymethacrylic Acids - toxicity Renilla - genetics Transfection
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Zusammenfassung:	Successful gene delivery vectors for clinical translation should have high transfection efficiency and minimal toxicity. In this work, well-defined poly(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) (PGEA) vectors with flanking cationic secondary amine and nonionic hydroxyl units were prepared via the ring-opening reaction of the pendant epoxide groups of poly(glycidyl methacrylate) with the amine moieties of ethanolamine. It was found that PGEA carriers possess very low toxicity (
ISSN:	1525-7797 1526-4602
DOI:	10.1021/bm100309y