Brønsted Acidic Ionic Liquid-Promoted Amidation of Quinoline N‑Oxides with Nitriles

Brønsted Acidic Ionic Liquid-Promoted Amidation of Quinoline N‑Oxides with Nitriles

An economic and eco-friendly straightforward synthesis of highly diversified N-acylated 2-aminoquinolines is successfully achieved via Brønsted acidic ionic liquid-promoted amidation of quinoline N-oxides with nitriles. The advantage of this present process is highlighted by its easily accessible st...

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Veröffentlicht in:ACS sustainable chemistry & engineering 2018-06, Vol.6 (6), p.7989-7994
Hauptverfasser: Xie, Long-Yong, Peng, Sha, Lu, Ling-Hui, Hu, Jue, Bao, Wen-Hu, Zeng, Fei, Tang, Zilong, Xu, Xinhua, He, Wei-Min
Format: Artikel
Sprache:eng
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Zusammenfassung:An economic and eco-friendly straightforward synthesis of highly diversified N-acylated 2-aminoquinolines is successfully achieved via Brønsted acidic ionic liquid-promoted amidation of quinoline N-oxides with nitriles. The advantage of this present process is highlighted by its easily accessible starting materials, excellent functional group tolerance, 100% atom economy, operational simplicity, and clean reaction profile.
ISSN:2168-0485
2168-0485
DOI:10.1021/acssuschemeng.8b01358