Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy

DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts (

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Bibliographische Detailangaben
Veröffentlicht in:	ACS nano 2020-11, Vol.14 (11), p.14831-14845
Hauptverfasser:	Zhang, Jimei, Zhao, Baochang, Chen, Shizhu, Wang, Yongchao, Zhang, Yuxuan, Wang, Yufei, Wei, Dengshuai, Zhang, Lingpu, Rong, Guanghua, Weng, Yuhua, Hao, Jifu, Li, Binglong, Hou, Xue-Qin, Kang, Xiaoxu, Zhao, Yao, Wang, Fuyi, Zhao, Yongxiang, Yu, Yingjie, Wu, Qin-Pei, Liang, Xing-Jie, Xiao, Haihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cisplatin - pharmacology Cross-Linking Reagents DNA - genetics DNA Adducts Glutathione Humans Hyperthermia, Induced
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	DNA alkylating agents generally kill tumor cells by covalently binding with DNA to form interstrand or intrastrand cross-links. However, in the case of cisplatin, only a few DNA adducts (
ISSN:	1936-0851 1936-086X
DOI:	10.1021/acsnano.0c03781