Novel 2‑Aryloxazoline Compounds Exhibit an Inhibitory Effect on Candida spp., Including Antifungal-Resistant Isolates

Novel 2‑Aryloxazoline Compounds Exhibit an Inhibitory Effect on Candida spp., Including Antifungal-Resistant Isolates

Because of the increased resistance to currently available antifungals, fungal infections represent a significant challenge to human health. Herein, we report the synthesis of 2-aryloxazoline derivatives from the reaction between l-threonine and derivatives of salicylic or naphthoic acid. In total,...

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Veröffentlicht in:ACS medicinal chemistry letters 2020-12, Vol.11 (12), p.2470-2475
Hauptverfasser: Argomedo, Luis M. Z, Barroso, Vinicius M, Barreiro, Cristiane S, Darbem, Mariana P, Ishida, Kelly, Stefani, Hélio A
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry, Medicinal
Letter
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
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Zusammenfassung:Because of the increased resistance to currently available antifungals, fungal infections represent a significant challenge to human health. Herein, we report the synthesis of 2-aryloxazoline derivatives from the reaction between l-threonine and derivatives of salicylic or naphthoic acid. In total, 26 compounds were obtained and tested against species of Candida, Cryptococcus, and Aspergillus. We found that all of the compounds inhibited the growth of Candida species at low concentrations (
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.0c00449