Photocatalytic Polyamine Depletion for the Treatment of Psoriasis

Psoriasis is an incurable autoinflammatory disorder associated with metabolic abnormalities. Excessive polyamine production in keratinocytes plays a vital role in the initiation and progression of psoriasis. In this study, we propose a new strategy to degrade polyamines and ameliorate psoriasis development based on the new type of polyoxometalate (POMs)-based silver material C32H100Ag6O98P2S16W24 (HT-1). HT-1 possessed efficient peroxidase (POD) and oxidase (OXD)-like activities for promoting reactive oxygen species (ROS) generation under visible light (VIS) irradiation. The generated ROS from HT-1 efficiently decreased the levels of polyamines and reduced IL-17A-induced psoriatic responses in keratinocytes. Meanwhile, photocatalytic depletion of polyamines by HT-1 also reduced the endosomal self-RNA sensing in DCs, impairing the maturation and T cells priming function of DC, thereby attenuating the development of psoriasis. In summary, this study may pave the way for a promising treatment approach for psoriasis, even for other autoinflammatory diseases.