Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions

Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions

Nanoparticles derived from FeCl3 containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45 °C. The entire aqueous reaction medium can be easily recycled using an “in-flask” extraction. Several tandem processes in one pot are illustrated, including a sequ...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS catalysis 2019-03, Vol.9 (3), p.2423-2431
Hauptverfasser: Handa, Sachin, Jin, Bo, Bora, Pranjal P, Wang, Ye, Zhang, Xiaohua, Gallou, Fabrice, Reilly, John, Lipshutz, Bruce H
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Nanoparticles derived from FeCl3 containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45 °C. The entire aqueous reaction medium can be easily recycled using an “in-flask” extraction. Several tandem processes in one pot are illustrated, including a sequence involving five steps (10 reactions) in good overall yield.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.9b00007