Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide

Incorporating Unbiased, Unactivated Aliphatic Alkenes in Pd(II)-Catalyzed Olefination of Benzyl Phosphonamide

The use of unbiased aliphatic alkene as the coupling partner for C–H olefination continues to be a challenging task. A suitable chelating directing group allowed ortho C–H olefination of benzyl phosphonamide with unactivated aliphatic alkenes. The broad substrate scope with respect to variation of b...

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Veröffentlicht in:ACS catalysis 2017-11, Vol.7 (11), p.7732-7736
Hauptverfasser: Seth, Kapileswar, Bera, Milan, Brochetta, Massimo, Agasti, Soumitra, Das, Ashis, Gandini, Andrea, Porta, Alessio, Zanoni, Giuseppe, Maiti, Debabrata
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Sprache:eng
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Zusammenfassung:The use of unbiased aliphatic alkene as the coupling partner for C–H olefination continues to be a challenging task. A suitable chelating directing group allowed ortho C–H olefination of benzyl phosphonamide with unactivated aliphatic alkenes. The broad substrate scope with respect to variation of benzyl phosphonamides and aliphatic alkenes as well as examples of sequential hetero-bis-olefinations offer diversity along with excellent linear/branch selectivity.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.7b02394