Scalable Aqueous Reversible Addition–Fragmentation Chain Transfer Photopolymerization-Induced Self-Assembly of Acrylamides for Direct Synthesis of Polymer Nanoparticles for Potential Drug Delivery Applications

The synthesis of polymer nanoparticles for potential drug delivery applications via photoinduced electron transfer–reversible addition–fragmentation chain transfer aqueous dispersion polymerizations employing Eosin Y/triethanol amine as catalytic system is described. A scalable synthesis procedure for the polymerization of poly­(dimethyl acrylamide)-b-(poly­(diaceteone-stat-dimethyl acrylamide)) is reported under visible light (λmax = 530 nm). A variety of solid contents and block lengths for the solvophilic and solvophobic blocks are investigated, expanding the compositional space of worms, jellyfish, and vesicles using flow chemistry. A simple two-step process using a coupled flow reactor setup is used without the need for intermediate purification.