Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites
The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape...
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| Veröffentlicht in: | ACS applied materials & interfaces 2020-09, Vol.12 (36), p.40673-40683 |
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| container_title | ACS applied materials & interfaces |
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| creator | Liu, Chen-Guang Tang, Han-Xiao Zheng, Xiang Yang, Da-Yun Zhang, Yang Zhang, Jian-Ting Kankala, Ranjith Kumar Wang, Shi-Bin Liu, Gang Chen, Ai-Zheng |
| description | The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo. |
| doi_str_mv | 10.1021/acsami.0c11739 |
| format | Article |
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It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.0c11739</identifier><identifier>PMID: 32786245</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacology ; Cell Death - drug effects ; Cell Membrane Permeability - drug effects ; Cells, Cultured ; Copper - chemistry ; Copper - metabolism ; Copper - pharmacology ; Disease Models, Animal ; Drug Screening Assays, Antitumor ; Female ; Functional Nanostructured Materials (including low-D carbon) ; Humans ; Hydroxides - chemistry ; Hydroxides - metabolism ; Hydroxides - pharmacology ; Infrared Rays ; Lysosomes - chemistry ; Lysosomes - metabolism ; Mammary Neoplasms, Experimental - diagnostic imaging ; Mammary Neoplasms, Experimental - drug therapy ; Mammary Neoplasms, Experimental - metabolism ; Mice ; Mice, Nude ; Nanocomposites - chemistry ; Particle Size ; Photoacoustic Techniques ; Photothermal Therapy ; Reactive Oxygen Species - metabolism ; Surface Properties</subject><ispartof>ACS applied materials & interfaces, 2020-09, Vol.12 (36), p.40673-40683</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a396t-d5debd439283267cae2cc8bac1539bbb376a00b60116eea7a005dbddaebc4553</citedby><cites>FETCH-LOGICAL-a396t-d5debd439283267cae2cc8bac1539bbb376a00b60116eea7a005dbddaebc4553</cites><orcidid>0000-0003-4081-9179 ; 0000-0003-2613-7286 ; 0000-0002-8442-3339 ; 0000-0002-5840-3406 ; 0000-0001-5999-8870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.0c11739$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.0c11739$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32786245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chen-Guang</creatorcontrib><creatorcontrib>Tang, Han-Xiao</creatorcontrib><creatorcontrib>Zheng, Xiang</creatorcontrib><creatorcontrib>Yang, Da-Yun</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Zhang, Jian-Ting</creatorcontrib><creatorcontrib>Kankala, Ranjith Kumar</creatorcontrib><creatorcontrib>Wang, Shi-Bin</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Chen, Ai-Zheng</creatorcontrib><title>Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Death - drug effects</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Cells, Cultured</subject><subject>Copper - chemistry</subject><subject>Copper - metabolism</subject><subject>Copper - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Functional Nanostructured Materials (including low-D carbon)</subject><subject>Humans</subject><subject>Hydroxides - chemistry</subject><subject>Hydroxides - metabolism</subject><subject>Hydroxides - pharmacology</subject><subject>Infrared Rays</subject><subject>Lysosomes - chemistry</subject><subject>Lysosomes - metabolism</subject><subject>Mammary Neoplasms, Experimental - diagnostic imaging</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Nanocomposites - chemistry</subject><subject>Particle Size</subject><subject>Photoacoustic Techniques</subject><subject>Photothermal Therapy</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Surface Properties</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwzAQhC0E4n3liHxGSvEjj-ZYtdBWqloE3KO1vRFBTRzZCZAzfxxDCzdOO6udGa0-Qq44G3Em-C1oD3U1YprzTOYH5JTncRyNRSIO_3Qcn5Az718ZS6VgyTE5kSIbpyJOTsnnGsFFy6Z04NBEE91Vb9ChoavBW29rpA_QvbzDQGcYBF02ptfhrAb6uHmic2zQ_fhLZ2u6ggFDDZ3ZXm2RLgbj7EdlMJratkVHn_ptGVa6hsZqW7fWVx36C3JUwtbj5X6ek-f7u-fpIlpt5svpZBWBzNMuMolBZWKZi7EUaaYBhdZjBZonMldKySwFxlTKOE8RIQtLYpQxgErHSSLPyWhXq5313mFZtK6qwQ0FZ8U3zGIHs9jDDIHrXaDtVY3mz_5LLxhudoYQLF5t75rw_n9tX90Pgig</recordid><startdate>20200909</startdate><enddate>20200909</enddate><creator>Liu, Chen-Guang</creator><creator>Tang, Han-Xiao</creator><creator>Zheng, Xiang</creator><creator>Yang, Da-Yun</creator><creator>Zhang, Yang</creator><creator>Zhang, Jian-Ting</creator><creator>Kankala, Ranjith Kumar</creator><creator>Wang, Shi-Bin</creator><creator>Liu, Gang</creator><creator>Chen, Ai-Zheng</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4081-9179</orcidid><orcidid>https://orcid.org/0000-0003-2613-7286</orcidid><orcidid>https://orcid.org/0000-0002-8442-3339</orcidid><orcidid>https://orcid.org/0000-0002-5840-3406</orcidid><orcidid>https://orcid.org/0000-0001-5999-8870</orcidid></search><sort><creationdate>20200909</creationdate><title>Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites</title><author>Liu, Chen-Guang ; Tang, Han-Xiao ; Zheng, Xiang ; Yang, Da-Yun ; Zhang, Yang ; Zhang, Jian-Ting ; Kankala, Ranjith Kumar ; Wang, Shi-Bin ; Liu, Gang ; Chen, Ai-Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-d5debd439283267cae2cc8bac1539bbb376a00b60116eea7a005dbddaebc4553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Death - drug effects</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Cells, Cultured</topic><topic>Copper - chemistry</topic><topic>Copper - metabolism</topic><topic>Copper - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Functional Nanostructured Materials (including low-D carbon)</topic><topic>Humans</topic><topic>Hydroxides - chemistry</topic><topic>Hydroxides - metabolism</topic><topic>Hydroxides - pharmacology</topic><topic>Infrared Rays</topic><topic>Lysosomes - chemistry</topic><topic>Lysosomes - metabolism</topic><topic>Mammary Neoplasms, Experimental - diagnostic imaging</topic><topic>Mammary Neoplasms, Experimental - drug therapy</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Nanocomposites - chemistry</topic><topic>Particle Size</topic><topic>Photoacoustic Techniques</topic><topic>Photothermal Therapy</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chen-Guang</creatorcontrib><creatorcontrib>Tang, Han-Xiao</creatorcontrib><creatorcontrib>Zheng, Xiang</creatorcontrib><creatorcontrib>Yang, Da-Yun</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Zhang, Jian-Ting</creatorcontrib><creatorcontrib>Kankala, Ranjith Kumar</creatorcontrib><creatorcontrib>Wang, Shi-Bin</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Chen, Ai-Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chen-Guang</au><au>Tang, Han-Xiao</au><au>Zheng, Xiang</au><au>Yang, Da-Yun</au><au>Zhang, Yang</au><au>Zhang, Jian-Ting</au><au>Kankala, Ranjith Kumar</au><au>Wang, Shi-Bin</au><au>Liu, Gang</au><au>Chen, Ai-Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2020-09-09</date><risdate>2020</risdate><volume>12</volume><issue>36</issue><spage>40673</spage><epage>40683</epage><pages>40673-40683</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>The overdeveloped lysosomes in cancer cells are gaining increasing attention toward more precise and effective organelle-targeted cancer therapy. It is suggested that rod/plate-like nanomaterials with an appropriate size exhibited a greater quantity and longer-term lysosomal enrichment, as the shape plays a notable role in the nanomaterial transmembrane process and subcellular behaviors. Herein, a biodegradable platform based on layered double hydroxide-copper sulfide nanocomposites (LDH-CuS NCs) is successfully prepared via in situ growth of CuS nanodots on LDH nanoplates. The as-prepared LDH-CuS NCs exhibited not only high photothermal conversion and near-infrared (NIR)-induced chemodynamic and photodynamic therapeutic efficacies, but also could achieve real-time in vivo photoacoustic imaging (PAI) of the entire tumor. LDH-CuS NCs accumulated in lysosomes would then generate extensive subcellular reactive oxygen species (ROS) in situ, leading to lysosomal membrane permeabilization (LMP) pathway-associated cell death both in vitro and in vivo.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>32786245</pmid><doi>10.1021/acsami.0c11739</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4081-9179</orcidid><orcidid>https://orcid.org/0000-0003-2613-7286</orcidid><orcidid>https://orcid.org/0000-0002-8442-3339</orcidid><orcidid>https://orcid.org/0000-0002-5840-3406</orcidid><orcidid>https://orcid.org/0000-0001-5999-8870</orcidid></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Death - drug effects Cell Membrane Permeability - drug effects Cells, Cultured Copper - chemistry Copper - metabolism Copper - pharmacology Disease Models, Animal Drug Screening Assays, Antitumor Female Functional Nanostructured Materials (including low-D carbon) Humans Hydroxides - chemistry Hydroxides - metabolism Hydroxides - pharmacology Infrared Rays Lysosomes - chemistry Lysosomes - metabolism Mammary Neoplasms, Experimental - diagnostic imaging Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Mice Mice, Nude Nanocomposites - chemistry Particle Size Photoacoustic Techniques Photothermal Therapy Reactive Oxygen Species - metabolism Surface Properties |
| title | Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites |
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