Smart Microenvironment-Responsive Organocopper(II) Supramolecular Polymers to Regulate the Stability and Anticancer Efficacy by Different Substituents

The search for chemotherapeutic drugs with a high efficiency and low toxicity continues to be a challenge in tumor treatment for scientists. Organometallic supramolecular polymers are an attractive option to achieve this goal, not only due to the fact that they possess both advantages of metal complexes and nanostructures but also because they are usually sensitive to pH. Here, we report the design and synthesis of a series novel smart microenvironment-responsive organocopper­(II) supramolecular polymers with various substituted ligands to regulate their stability and anticancer efficacy. The investigation of the possible mechanisms revealed that the organocopper­(II) polymers enter cancer cells through endocytosis and then induce apoptosis of cancer cells. Furthermore, the in vivo anticancer efficacy study demonstrated that these organocopper­(II) polymers inhibited the tumor growth effectively without damage to the major organs. Overall, the organocopper­(II) supramolecular polymers present a promising pathway to achieve high-efficiency and low-toxicity chemotherapy.