Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors
Light-mediated therapy has many unique merits but monotherapy strategies rarely completely inhibit tumor growth because resistance often develops. Combination therapy is a promising strategy in oncology and has demonstrated superior safety and efficacy over monotherapy. Here, we conjugated a scintil...
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| Veröffentlicht in: | ACS applied materials & interfaces 2020-03, Vol.12 (11), p.12591-12599 |
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| container_title | ACS applied materials & interfaces |
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| creator | Luo, Li Sun, Wenjing Feng, Yushuo Qin, Ruixue Zhang, Jinghui Ding, Dandan Shi, Tianhang Liu, Xiangmei Chen, Xiaoyuan Chen, Hongmin |
| description | Light-mediated therapy has many unique merits but monotherapy strategies rarely completely inhibit tumor growth because resistance often develops. Combination therapy is a promising strategy in oncology and has demonstrated superior safety and efficacy over monotherapy. Here, we conjugated a scintillator complex and gold nanorod nanosensitizer for dual-modal image-guided photothermal and X-ray-induced photodynamic therapy (PDT). Lanthanide complexes were successfully conjugated and offer excellent X-ray-excited optical luminescence for PDT effects. The strong near-infrared (NIR) light and X-ray absorption abilities of gold nanorods make the nanosensitizer function as both a photothermal agent for photothermal therapy and a radiosensitizer for enhanced radiotherapy. The studies in vitro and in vivo demonstrated that the nanosensitizer offers good dual-modal imaging capability and significantly suppresses tumor progression under NIR light and X-ray irradiation. This work shows the great potential of conjugating scintillator lanthanide complexes and gold nanosensitizers for multimodal image-guided therapy of deep-seated tumors. |
| doi_str_mv | 10.1021/acsami.0c01189 |
| format | Article |
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This work shows the great potential of conjugating scintillator lanthanide complexes and gold nanosensitizers for multimodal image-guided therapy of deep-seated tumors.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.0c01189</identifier><identifier>PMID: 32105438</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Cell Line, Tumor ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Fluorescent Dyes - chemistry ; Gold - chemistry ; Lanthanoid Series Elements - chemistry ; Mice ; Mice, Inbred BALB C ; Nanotubes - chemistry ; Optical Imaging - methods ; Photochemotherapy - methods ; Radiation-Sensitizing Agents - chemistry ; Radiation-Sensitizing Agents - pharmacology ; Theranostic Nanomedicine ; X-Rays</subject><ispartof>ACS applied materials & interfaces, 2020-03, Vol.12 (11), p.12591-12599</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a396t-9711914541b695e1be6674e3430eaf850629057b9c6a93da162eeda06927d8393</citedby><cites>FETCH-LOGICAL-a396t-9711914541b695e1be6674e3430eaf850629057b9c6a93da162eeda06927d8393</cites><orcidid>0000-0002-9622-0870 ; 0000-0002-6699-2300</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.0c01189$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.0c01189$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32105438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Feng, Yushuo</creatorcontrib><creatorcontrib>Qin, Ruixue</creatorcontrib><creatorcontrib>Zhang, Jinghui</creatorcontrib><creatorcontrib>Ding, Dandan</creatorcontrib><creatorcontrib>Shi, Tianhang</creatorcontrib><creatorcontrib>Liu, Xiangmei</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><creatorcontrib>Chen, Hongmin</creatorcontrib><title>Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>Light-mediated therapy has many unique merits but monotherapy strategies rarely completely inhibit tumor growth because resistance often develops. Combination therapy is a promising strategy in oncology and has demonstrated superior safety and efficacy over monotherapy. Here, we conjugated a scintillator complex and gold nanorod nanosensitizer for dual-modal image-guided photothermal and X-ray-induced photodynamic therapy (PDT). Lanthanide complexes were successfully conjugated and offer excellent X-ray-excited optical luminescence for PDT effects. The strong near-infrared (NIR) light and X-ray absorption abilities of gold nanorods make the nanosensitizer function as both a photothermal agent for photothermal therapy and a radiosensitizer for enhanced radiotherapy. The studies in vitro and in vivo demonstrated that the nanosensitizer offers good dual-modal imaging capability and significantly suppresses tumor progression under NIR light and X-ray irradiation. This work shows the great potential of conjugating scintillator lanthanide complexes and gold nanosensitizers for multimodal image-guided therapy of deep-seated tumors.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Gold - chemistry</subject><subject>Lanthanoid Series Elements - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nanotubes - chemistry</subject><subject>Optical Imaging - methods</subject><subject>Photochemotherapy - methods</subject><subject>Radiation-Sensitizing Agents - chemistry</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Theranostic Nanomedicine</subject><subject>X-Rays</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AUhQdRbK1uXcqshdSZzGSSWUrUWqg_YAV34SYzaVOSTJgkYHa-gviGPokpabtzdS_c75x7OAhdUjKlxKU3kNRQZFOSEEoDeYTGVHLuBK7nHh92zkforK43hAjmEu8UjZhLicdZMEY_oSk37QqazJTYpBjwW5KVTZbn0BiLQ1NUuf7EUCo8M7nCz1Aaa1SN0_5610LuPBkFOZ4XsNLOrM2UVvh1bRrTrLUt-stW-vH79W2hc-alapM9oLqyj57gZQ9C1W2_L9vC2PocnaSQ1_piNyfo_eF-GT46i5fZPLxdOMCkaBzpUyop9ziNhfQ0jbUQPteMM6IhDTwiXEk8P5aJAMkUUOFqrYAI6foqYJJN0HTwTaypa6vTqLJZAbaLKIm27UZDu9Gu3V5wNQiqNi60OuD7OnvgegB6YbQxrS37_P-5_QE1AobZ</recordid><startdate>20200318</startdate><enddate>20200318</enddate><creator>Luo, Li</creator><creator>Sun, Wenjing</creator><creator>Feng, Yushuo</creator><creator>Qin, Ruixue</creator><creator>Zhang, Jinghui</creator><creator>Ding, Dandan</creator><creator>Shi, Tianhang</creator><creator>Liu, Xiangmei</creator><creator>Chen, Xiaoyuan</creator><creator>Chen, Hongmin</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid><orcidid>https://orcid.org/0000-0002-6699-2300</orcidid></search><sort><creationdate>20200318</creationdate><title>Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors</title><author>Luo, Li ; Sun, Wenjing ; Feng, Yushuo ; Qin, Ruixue ; Zhang, Jinghui ; Ding, Dandan ; Shi, Tianhang ; Liu, Xiangmei ; Chen, Xiaoyuan ; Chen, Hongmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-9711914541b695e1be6674e3430eaf850629057b9c6a93da162eeda06927d8393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Gold - chemistry</topic><topic>Lanthanoid Series Elements - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nanotubes - chemistry</topic><topic>Optical Imaging - methods</topic><topic>Photochemotherapy - methods</topic><topic>Radiation-Sensitizing Agents - chemistry</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Theranostic Nanomedicine</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Sun, Wenjing</creatorcontrib><creatorcontrib>Feng, Yushuo</creatorcontrib><creatorcontrib>Qin, Ruixue</creatorcontrib><creatorcontrib>Zhang, Jinghui</creatorcontrib><creatorcontrib>Ding, Dandan</creatorcontrib><creatorcontrib>Shi, Tianhang</creatorcontrib><creatorcontrib>Liu, Xiangmei</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><creatorcontrib>Chen, Hongmin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Li</au><au>Sun, Wenjing</au><au>Feng, Yushuo</au><au>Qin, Ruixue</au><au>Zhang, Jinghui</au><au>Ding, Dandan</au><au>Shi, Tianhang</au><au>Liu, Xiangmei</au><au>Chen, Xiaoyuan</au><au>Chen, Hongmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2020-03-18</date><risdate>2020</risdate><volume>12</volume><issue>11</issue><spage>12591</spage><epage>12599</epage><pages>12591-12599</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Light-mediated therapy has many unique merits but monotherapy strategies rarely completely inhibit tumor growth because resistance often develops. Combination therapy is a promising strategy in oncology and has demonstrated superior safety and efficacy over monotherapy. Here, we conjugated a scintillator complex and gold nanorod nanosensitizer for dual-modal image-guided photothermal and X-ray-induced photodynamic therapy (PDT). Lanthanide complexes were successfully conjugated and offer excellent X-ray-excited optical luminescence for PDT effects. The strong near-infrared (NIR) light and X-ray absorption abilities of gold nanorods make the nanosensitizer function as both a photothermal agent for photothermal therapy and a radiosensitizer for enhanced radiotherapy. The studies in vitro and in vivo demonstrated that the nanosensitizer offers good dual-modal imaging capability and significantly suppresses tumor progression under NIR light and X-ray irradiation. This work shows the great potential of conjugating scintillator lanthanide complexes and gold nanosensitizers for multimodal image-guided therapy of deep-seated tumors.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>32105438</pmid><doi>10.1021/acsami.0c01189</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9622-0870</orcidid><orcidid>https://orcid.org/0000-0002-6699-2300</orcidid></addata></record> |
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| source | MEDLINE; ACS Publications |
| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects Fluorescent Dyes - chemistry Gold - chemistry Lanthanoid Series Elements - chemistry Mice Mice, Inbred BALB C Nanotubes - chemistry Optical Imaging - methods Photochemotherapy - methods Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Theranostic Nanomedicine X-Rays |
| title | Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X‑ray-Induced Photodynamic Therapy of Tumors |
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