Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici

Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici

By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A–E (1 and 3–6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked t...

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Veröffentlicht in:Organic letters 2017-09, Vol.19 (17), p.4700-4703
Hauptverfasser: Zheng, Yanjing, Ma, Ke, Lyu, Haining, Huang, Ying, Liu, Hongwei, Liu, Ling, Che, Yongsheng, Liu, Xingzhong, Zou, Huixi, Yin, Wen-Bing
Format: Artikel
Sprache:eng
Schlagworte:
COP9 Signalosome Complex
Molecular Structure
Multiprotein Complexes
Xylariales
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Zusammenfassung:By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A–E (1 and 3–6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b02346