A Two-Directional Synthesis of (+)-β-Isosparteine

A Two-Directional Synthesis of (+)-β-Isosparteine

A two-directional synthesis of (+)-β-isosparteine is described in five steps from glutaric acid, where the entire carbon and nitrogen backbone of the alkaloid, possessing the requisite relative and absolute stereochemistry at its four stereogenic centers, is assembled using a double imino-aldol reac...

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Veröffentlicht in:Organic letters 2017-07, Vol.19 (13), p.3502-3504
Hauptverfasser: Al-Saffar, Firas M, Brown, Richard C. D
Format: Artikel
Sprache:eng
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Zusammenfassung:A two-directional synthesis of (+)-β-isosparteine is described in five steps from glutaric acid, where the entire carbon and nitrogen backbone of the alkaloid, possessing the requisite relative and absolute stereochemistry at its four stereogenic centers, is assembled using a double imino-aldol reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01475