Transition-Metal-Free Lactonization of sp 2 C-H Bonds with CO 2

Transition-Metal-Free Lactonization of sp 2 C-H Bonds with CO 2

The transition-metal-free lactonization of heteroaryl and alkenyl C-H bonds with carbon dioxide is reported to synthesize important coumarin derivatives in moderate to excellent yields. These redox-neutral reactions feature a broad substrate scope, good functional group tolerance, facile scalability...

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Veröffentlicht in:Organic letters 2017-01, Vol.19 (2), p.396-399
Hauptverfasser: Zhang, Zhen, Ju, Tao, Miao, Meng, Han, Jie-Lian, Zhang, Yi-Han, Zhu, Xing-Yong, Ye, Jian-Heng, Yu, Da-Gang, Zhi, Yong-Gang
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Sprache:eng
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Zusammenfassung:The transition-metal-free lactonization of heteroaryl and alkenyl C-H bonds with carbon dioxide is reported to synthesize important coumarin derivatives in moderate to excellent yields. These redox-neutral reactions feature a broad substrate scope, good functional group tolerance, facile scalability, and easy product derivatization.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b03601