Rh(III)-Catalyzed [3 + 3]-Coupling Cyclization of 3‑Hydroxyisoindolinones with Carbenoids: Rapid Access to Spirolactam Skeletons

Rh(III)-Catalyzed [3 + 3]-Coupling Cyclization of 3‑Hydroxyisoindolinones with Carbenoids: Rapid Access to Spirolactam Skeletons

A Rh­(III)-catalyzed [3 + 3]-coupling cyclization of 3-hydroxy-3-phenylisoindolinone with carbenoids has been developed. The method provides an efficient approach to access polyfunctionalized-spiro­[isochromene-1,1′-isoindolin]-3′-ones with good to excellent reaction conversions.

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Veröffentlicht in:Organic letters 2024-09, Vol.26 (36), p.7728-7732
Hauptverfasser: Wang, Chengjie, Jiang, Huanfeng, Zeng, Wei
Format: Artikel
Sprache:eng
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Zusammenfassung:A Rh­(III)-catalyzed [3 + 3]-coupling cyclization of 3-hydroxy-3-phenylisoindolinone with carbenoids has been developed. The method provides an efficient approach to access polyfunctionalized-spiro­[isochromene-1,1′-isoindolin]-3′-ones with good to excellent reaction conversions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.4c02889