Fluoride-Catalyzed Cross-Coupling of Silylamides to CF 3 -Acrylates: Access to Highly Functionalized Trifluoromethylated and Quaternary Fluorinated Molecular Architectures

Fluoride-Catalyzed Cross-Coupling of Silylamides to CF 3 -Acrylates: Access to Highly Functionalized Trifluoromethylated and Quaternary Fluorinated Molecular Architectures

A direct and simple catalytic coupling of nonfluorinated and fluorinated silylbutenamides with β-CF α,β-unsaturated esters mediated by fluoride ion was carried out. The transformation proceeded with excellent yields to afford new, highly functionalized trifluoromethylated and quaternary fluorinated...

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Veröffentlicht in:Organic letters 2024-07, Vol.26 (29), p.6130-6135
1. Verfasser: Bouzbouz, Samir
Format: Artikel
Sprache:eng
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Zusammenfassung:A direct and simple catalytic coupling of nonfluorinated and fluorinated silylbutenamides with β-CF α,β-unsaturated esters mediated by fluoride ion was carried out. The transformation proceeded with excellent yields to afford new, highly functionalized trifluoromethylated and quaternary fluorinated products.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.4c01895