Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH 3 OTf

Iron-Catalyzed Ring Expansion of Cyclobutanols for the Synthesis of 1-Pyrrolines by Using MsONH 3 OTf

The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH OTf) has been developed. This one-pot procedure achieves C-N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthesized in moderate to good yields under mild conditions.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2022-01, Vol.24 (2), p.771-775
Hauptverfasser: Zhuang, Daijiao, Gatera, Tharcisse, An, Zhenyu, Yan, Rulong
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The synthesis of 1-pyrrolines from cyclobutanol derivatives and an aminating reagent (MsONH OTf) has been developed. This one-pot procedure achieves C-N bond/C═N bond formation via ring expansion. A series of 1-pyrroline derivatives are synthesized in moderate to good yields under mild conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c04304