Isolable Pyridinium Trifluoromethoxide Salt for Nucleophilic Trifluoromethoxylation

Isolable Pyridinium Trifluoromethoxide Salt for Nucleophilic Trifluoromethoxylation

An isolable pyridinium trifluoromethoxide salt is prepared from the reaction of 4-dimethylaminopyridine with the commercially available liquid 2,4-dinitro­(trifluoromethoxy)­benzene. The salt is an effective trifluoromethoxide source for SN2 reactions to form trifluoromethyl ethers.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2021-07, Vol.23 (13), p.5138-5142
Hauptverfasser: Duran-Camacho, Geraldo, Ferguson, Devin M, Kampf, Jeff W, Bland, Douglas C, Sanford, Melanie S
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An isolable pyridinium trifluoromethoxide salt is prepared from the reaction of 4-dimethylaminopyridine with the commercially available liquid 2,4-dinitro­(trifluoromethoxy)­benzene. The salt is an effective trifluoromethoxide source for SN2 reactions to form trifluoromethyl ethers.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c01664