Development of a C 2‑Symmetric Chiral aza Spirocyclic Diol

Development of a C 2‑Symmetric Chiral aza Spirocyclic Diol

A C 2-symmetric chiral spirocyclic diol aza-SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of aza-SPINOL to other chiral ligands as well as the prelim...

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Veröffentlicht in:Organic letters 2020-04, Vol.22 (8), p.3110-3113
Hauptverfasser: Guo, Weicong, Liu, Qinzhe, Jiang, Jijun, Wang, Jun
Format: Artikel
Sprache:eng
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Zusammenfassung:A C 2-symmetric chiral spirocyclic diol aza-SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of aza-SPINOL to other chiral ligands as well as the preliminary investigation of the related bisphosphine ligand in the desymmetrization of bisallylic amide were reported.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c00858