P‑Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

P‑Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

Asymmetric copper-catalyzed allylic alkylation between allyl bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantiosele...

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Veröffentlicht in:Organometallics 2019-10, Vol.38 (20), p.4003-4013
Hauptverfasser: Xiong, Wenrui, Xu, Guangqing, Yu, Xinhong, Tang, Wenjun
Format: Artikel
Sprache:eng
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Zusammenfassung:Asymmetric copper-catalyzed allylic alkylation between allyl bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.
ISSN:0276-7333
1520-6041
DOI:10.1021/acs.organomet.9b00194