T3P-Mediated N–N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5‑a]pyridines

T3P-Mediated N–N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5‑a]pyridines

Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]­triazolo­[1,5-a]­pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazo...

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Veröffentlicht in:Organic process research & development 2019-11, Vol.23 (11), p.2510-2515
Hauptverfasser: Ayothiraman, Rajaram, Bandaru, Durgarao, Paranthaman, Ranjitha, Fenster, Michaël, Eastgate, Martin D, Vaidyanathan, Rajappa
Format: Artikel
Sprache:eng
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Zusammenfassung:Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]­triazolo­[1,5-a]­pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazolopyridines in good to excellent yields and purities.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00396