Identification and Synthesis of a Nitrophenyl Metabolite of Rinskor Active from Terrestrial Aerobic Soil Studies

To support the registration of crop protection products, over 100 regulatory studies are conducted for an active ingredient. These studies allow regulatory agencies and the agroscience industry to ensure that new crop protection products meet the requirements for users, consumers, and the environment prior to their use in agriculture. Rinskor active is a Corteva Agriscience auxinic herbicide, which was launched in 2018 for the control of broadleaf weeds, grass weeds, and sedges in rice fields. To support the registration of Rinskor, four terrestrial aerobic soil studies were conducted to determine the soil degradation profile and rate of the active ingredient. These studies were conducted using carbon-14-labeled active ingredient test systems. From these studies, three major metabolites were generated, and the structures of these metabolites had to be identified via the preparation of an authentic standard of each metabolite. This Article discusses the identification and synthesis of one of the major metabolites, a nitrophenyl metabolite, formed from terrestrial aerobic soil studies.