Nitro-Aldol Approach for Commercial Manufacturing of Fenspiride Hydrochloride

Nitro-Aldol Approach for Commercial Manufacturing of Fenspiride Hydrochloride

An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced foll...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic process research & development 2019-06, Vol.23 (6), p.1252-1256
Hauptverfasser: Pramanik, Chinmoy, Bapat, Kiran, Patil, Pradip, Kotharkar, Sandeep, More, Yogesh, Gotrane, Dinkar, Chaskar, Sudhir P, Mahajan, Ulhas, Tripathy, Narendra K
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00022