Stereoselective Acetalization for the Synthesis of Liquid-Crystal Compounds Possessing a trans-2,5-Disubstituted 1,3-Dioxane Ring with Saturated Aqueous Solutions of Inorganic Salts
Stereoselective process for the synthesis of trans-2,5-disubstituted 1,3-dioxane derivatives, which are important liquid-crystal compounds, was developed. The acetalization reaction between aldehydes and 2-substituted 1,3-propanediols in the presence of acids gave the corresponding 2,5-disubstituted...
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| Veröffentlicht in: | Organic process research & development 2019-04, Vol.23 (4), p.477-483 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Stereoselective process for the synthesis of trans-2,5-disubstituted 1,3-dioxane derivatives, which are important liquid-crystal compounds, was developed. The acetalization reaction between aldehydes and 2-substituted 1,3-propanediols in the presence of acids gave the corresponding 2,5-disubstituted 1,3-dioxane derivatives with high trans selectivity (trans/cis = >96: |
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| ISSN: | 1083-6160 1520-586X |
| DOI: | 10.1021/acs.oprd.8b00408 |