A Manufacturing Process to an Intermediate in the Synthesis of Acalabrutinib

A Manufacturing Process to an Intermediate in the Synthesis of Acalabrutinib

Optimization and application of the reported synthesis of (3-chloropyrazin-2-yl)­methanamine 3 have provided a high yielding, fully telescoped procedure to key intermediate 5 in the synthesis of acalabrutinib.

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Veröffentlicht in:Organic process research & development 2018-10, Vol.22 (10), p.1458-1460
Hauptverfasser: Chen, Bo, Golden, Michael, Li, Zhonglian, Xu, Liwen, Xu, Zhaofu, Yao, Xiaolong
Format: Artikel
Sprache:eng
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Zusammenfassung:Optimization and application of the reported synthesis of (3-chloropyrazin-2-yl)­methanamine 3 have provided a high yielding, fully telescoped procedure to key intermediate 5 in the synthesis of acalabrutinib.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.8b00287