Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations a...

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Veröffentlicht in:Organic process research & development 2018-10, Vol.22 (10), p.1448-1452
Hauptverfasser: Gardiner, James, Nguyen, Xuan, Genet, Charlotte, Horne, Mike D, Hornung, Christian H, Tsanaktsidis, John
Format: Artikel
Sprache:eng
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Zusammenfassung:Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic hydrogenations and the rapid production of the target molecule without the need for catalyst removal or recovery.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.8b00153