Practical Isolation of the (1R,2R)‑Enantiomer from a Racemic cis/trans Mixture of 2‑Methyl-1-cyclohexanamine
2-Methyl-1-cyclohexanamine exists in four stereoisomeric forms. Although it is a simple compound, none of the stereoisomers is readily available in its pure form. We herein described a crystallization method identified by a salt screen (diastereomeric salt formation) allowing the isolation of a sing...
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Veröffentlicht in: | Organic process research & development 2017-11, Vol.21 (11), p.1822-1827 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | 2-Methyl-1-cyclohexanamine exists in four stereoisomeric forms. Although it is a simple compound, none of the stereoisomers is readily available in its pure form. We herein described a crystallization method identified by a salt screen (diastereomeric salt formation) allowing the isolation of a single trans enantiomer from a readily available commercial source consisting of a mixture of all four stereoisomers. |
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ISSN: | 1083-6160 1520-586X |
DOI: | 10.1021/acs.oprd.7b00263 |