Highly Productive α‑Alkylation of Ketones with Alcohols Mediated by an Ir–Oxalamidato/Solid Base Catalyst System

Highly Productive α‑Alkylation of Ketones with Alcohols Mediated by an Ir–Oxalamidato/Solid Base Catalyst System

An Ir–oxalamidato complex in combination with a solid base (e.g., magnesium aluminometasilicate/Ca­(OH)2) significantly improved the catalyst productivity in α-alkylation of methyl ketones with primary alcohols. Optimization through systematic variation of the oxalamidato ligand led to a practical t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic process research & development 2020-11, Vol.24 (11), p.2772-2779
Hauptverfasser: Shimizu, Hideo, Maeda, Hironori, Nara, Hideki
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An Ir–oxalamidato complex in combination with a solid base (e.g., magnesium aluminometasilicate/Ca­(OH)2) significantly improved the catalyst productivity in α-alkylation of methyl ketones with primary alcohols. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000–40 000.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.0c00362