Access to Amphiphilic Cis-Configurated Polyamide‑3 Using Alcohols as Initiators

The synthesis of polyamide-3 from 4a,5,8,8a-tetrahydro-1H-benzo­[d]­[1,3]­oxazine-2,4-dione (β-NCA, 1) using methanol, dye (Disperse Red 13), and poly­(ethylene glycol) as initiator is described. The ring-opening polymerization under release of CO2 produces polyamides-3 with definite terminal groups, high purity, and relatively narrow dispersity. This route was used for preparation of block copolymers from as an example.