Molecular Engineering of Injectable, Fast Self-Repairing Hydrogels with Tunable Gelation Time: Characterization by Diffusing Wave Spectroscopy

Molecular Engineering of Injectable, Fast Self-Repairing Hydrogels with Tunable Gelation Time: Characterization by Diffusing Wave Spectroscopy

Injectable and self-repairing hydrogels with tunable gelation time have excellent application prospects in drug release and tissue engineering. In this study, we synthesized the above hydrogels through acylhydrazone bonds between the polyacrylate containing the aldehyde group and azobenzene group (P...

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Veröffentlicht in:Macromolecules 2022-08, Vol.55 (15), p.6474-6486
Hauptverfasser: Xue, Xiaoqiang, Liang, Kang, Huang, Wenyan, Yang, Hongjun, Jiang, Li, Jiang, Qimin, Jiang, Tao, Lin, Binzhe, Chen, Yangjing, Jiang, Bibiao, Komarneni, Sridhar
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Sprache:eng
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Zusammenfassung:Injectable and self-repairing hydrogels with tunable gelation time have excellent application prospects in drug release and tissue engineering. In this study, we synthesized the above hydrogels through acylhydrazone bonds between the polyacrylate containing the aldehyde group and azobenzene group (P­(Azo-co-EGMA)) and the P­(N-isopropylacrylamide-co-acrylhydrazide) containing the hydrazide group (P­(NIPAM-co-AH)). The gelation time (t sol–gel) could be controlled from a few seconds (
ISSN:0024-9297
1520-5835
DOI:10.1021/acs.macromol.2c00899