Induction Heating Efficiency of Water-Dispersible Mn 0.5 Fe 2.5 O 4 @YVO 4 :Eu 3+ Magnetic-Luminescent Nanocomposites in an Acceptable ac Magnetic Field: Hemocompatibility and Cytotoxicity Studies

Not many reports are available on magnetic-luminescent nanocomposites for cancer hyperthermia applications. Further, such nanocomposites on Mn -doped iron oxide may be available rather rarely. Studies on the induction heating properties within the threshold magnetic field and frequency factors are still rare. In most cases, magnetic nanoparticles are studied for hyperthermia and lanthanide-doped luminescent nanoparticles for certain biomedical applications. Here, we report on water-dispersible superparamagnetic manganese-doped iron oxide (Mn Fe O ) nanoparticles and a polyethylene glycol6000-coated magnetic-luminescent nanocomposite. The nanocomposite is composed of magnetic Mn Fe O (average size 10-20 nm) nanoparticles and red-emitting YVO :Eu (average size 40-50 nm) nanoparticles. These magnetic nanoparticles and nanocomposites are studied for their induction heating abilities at different acceptable Hf values ( H, strength of alternating magnetic field and f, the operating frequency). The operational Hf values lie in the ranges of 2.15 × 10 to 4.58 × 10 kA m s that are well below the threshold limit of 5 × 10 kA m s . A specific absorption rate as high as 132 and 63 W/g, respectively, for Mn Fe O and Mn Fe O @YVO :Eu , can be achieved. The rate of heating and the temperature achieved with time can be tuned with concentrations as well as magnetic constituents in the nanocomposites. Hemocompatibility analysis revealed high blood compatibility with