Copper-Catalyzed Cross-Dehydrogenative N 2‑Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N‑Amidoalkylation of NH-1,2,3-Triazoles

Copper-Catalyzed Cross-Dehydrogenative N 2‑Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N‑Amidoalkylation of NH-1,2,3-Triazoles

An efficient copper-catalyzed C–N bond formation by N–H/C–H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N 2-selectivities whe...

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Veröffentlicht in:Journal of organic chemistry 2017-06, Vol.82 (12), p.6163-6171
Hauptverfasser: Deng, Xiaocong, Lei, Xue, Nie, Gang, Jia, Lihui, Li, Yuanxiang, Chen, Yunfeng
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient copper-catalyzed C–N bond formation by N–H/C–H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N 2-selectivities when 4,5-disubstituted NH-1,2,3-triazoles served as the substrates.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b00752