Iodine-Mediated δ-Amination of sp 3 C-H Bonds

Iodine-Mediated δ-Amination of sp 3 C-H Bonds

We present a direct δ-amination reaction of sp C-H bonds, employing molecular iodine (I ) as the sole oxidant under transition-metal-free conditions. This remote C-H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic deri...

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Veröffentlicht in:Journal of organic chemistry 2024-03, Vol.89 (5), p.3481-3490
Hauptverfasser: Ye, Wenjun, Xiong, Hanyu, Wang, Manman, Chang, Junbiao, Yu, Wenquan
Format: Artikel
Sprache:eng
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Zusammenfassung:We present a direct δ-amination reaction of sp C-H bonds, employing molecular iodine (I ) as the sole oxidant under transition-metal-free conditions. This remote C-H functionalization approach is operationally simple and provides facile, efficient access to pyrrolidines and related heterocyclic derivatives from readily accessible substrates.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02901