Synthetic Utilization of 2 H -Heptafluoropropane: Ionic 1,4-Addition to Electron-Deficient Carbon-Carbon Unsaturated Bonds
We have found a novel method for introducing heptafluoro-2-propyl CF(CF ) groups into carbon-carbon unsaturated bonds via a nucleophilic reaction using 2 -heptafluoropropane as the source of CF(CF ) groups. The reaction involves the nucleophilic addition of a heptafluoro-2-propyl anion, generated by...
Gespeichert in:
Veröffentlicht in: | Journal of organic chemistry 2024-03, Vol.89 (6), p.3962-3969 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We have found a novel method for introducing heptafluoro-2-propyl CF(CF
)
groups into carbon-carbon unsaturated bonds via a nucleophilic reaction using 2
-heptafluoropropane as the source of CF(CF
)
groups. The reaction involves the nucleophilic addition of a heptafluoro-2-propyl anion, generated by treating 2
-heptafluoropropane with a fluoride ion, to various electron-deficient unsaturated compounds. This allows the easy synthesis of various aliphatic compounds containing heptafluoro-2-propyl groups. |
---|---|
ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.3c02798 |