Determination and Analysis of Solubility of 2‑Chloromethyl-4-methylquinazoline in Different Solvent Systems at Different Temperatures (T = 281.15–331.15 K)

In the present study, we focused on the solubility of 2-chloromethyl-4-methylquinazoline. By the gravimetric method, the solubility of 2-chloromethyl-4-methylquinazoline was measured in cyclohexane, n-hexane, acetonitrile, tetrahydrofuran, acetone, ethyl acetate, n-propanol, ethanol, isopropanol, and butyl alcohol and in (s) and (cyclohexane + ethyl acetate) binary solvent mixtures from 281.15 to 331.15 K under atmospheric pressure. For all solubility data processing, we used the modified Apelblat model and the Buchowski–Ksiazaczak λh model to fit. For the solubility data of (n-hexane + acetone) and (cyclohexane + ethyl acetate) binary solvent mixtures, two binary solvent fitting models [combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model and Jouyban–Acree model] and the modified Apelblat model were used to fit. According to the fitting results, it could be seen that the modified Apelblat model had a good correlation with the solubility data of 2-chloromethyl-4-methylquinazoline in both pure and binary solvent systems. The experimental data showed that n-hexane or cyclohexane could be used as effective antisolvents.