Clouding and Thermodynamic Characteristics of Triton X‑100 in the Presence of Ciprofloxacin Hydrochloride: Influence of Polyols

Herein, the cloud point (CP) measurement of Triton X-100 (TX-100) in aqueous/polyols medium has been performed in the absence/presence of ciprofloxacin hydrochloride (CFH) antibiotic drug and demonstrated in detail. The executed CP values of TX-100 in H2O/polyols were obtained to be decreased with an increase of concentration of TX-100 up to a certain value, and then increased with the further increase of the concentration of TX-100. The CP values were reduced in the presence of CFH in all cases. The obtained CP values of TX-100 were lower in the presence of polyols as compared to that in an aqueous medium and reduced further with the subsequent rise of the polyols concentration. The Gibbs free energy of clouding (ΔG c 0) was positive in all cases. The enthalpy of clouding (ΔH c 0) and entropy of clouding (ΔS c 0) as well as transfer properties of the clouding of TX-100 were evaluated in aqueous/polyols media in the absence/attendance of CFH and discussed thoroughly. The more spontaneous clouding phenomenon in the presence of polyols is indicated by the negative value of free energy of transfer (ΔG c,tr 0). The entropy–enthalpy compensation was observed in all cases studied.