Volumetric Properties of Local Anesthetical Drug Lidocaine Hydrochloride in Aqueous and in Aqueous NaCl Solutions at Different Temperatures

We report in this communication, the data on density measurements of binary aqueous solutions of lidocaine hydrochloride LC·HCl (0.00978 to 0.25412 mol·kg–1) as well as for ternary aqueous solutions containing a fixed concentration (0.09787 mol·kg–1 and 1.00764 mol·kg–1) of sodium chloride (NaCl) and varying the concentration (0.02046 to 0.24929 mol·kg–1) of LC·HCl at 288.15, 293.15, 298.15, 303.15, and 308.15 K. The density data are used to determine apparent molar volume (V ϕ) of the drug LC·HCl molecule at finite concentrations as well as apparent molar volume at infinitely dilute solutions (V ϕ 0) in water and in aqueous NaCl solutions. The limiting apparent molar expansivity (E ϕ 0) parameter of LC·HCl in binary and ternary aqueous NaCl solutions at 293.15, 298.15, and 303.15 K have also been computed. The transfer volumes Δtr V ϕ 0, that is, volume change occurring when LC·HCl is transferred from water to aqueous NaCl solutions, are calculated. All these results are analyzed and discussed on the basis of solute–solvent, lidocaine cation–cation, and embrionic micelle forming interactions in aqueous salt solutions.