Determination, Correlation, and Application of Sodium l‑Ascorbate Solubility in Nine Pure Solvents and Two Binary Solvents at Temperatures from 278.15 to 323.15 K

The solubility data of sodium l-ascorbate in water, methanol, ethanol, acetone, chloroform, ethyl acetate, isopropyl alcohol, isobutyl alcohol, n-hexane, water–methanol mixture and water–ethanol mixture have been determined in the temperatures range of 278.15–323.15 K by a static analytic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation, CNIBS/R-K model, and Jouyban–Acree model. On the basis of the solubility data, a novel model-free design approach (semisupersaturation control, SSSC) for combined cooling and antisolvent crystallization (CCAC) processes has been proposed and evaluated for sodium l-ascorbate in a methanol–water mixture. This approach can be easily implemented without complicated online monitors. Sodium l-ascorbate crystals with large and uniform morphology were obtained using the CCAC process, which was designed by the SSSC approach.